PGV-o Stop breast cancer
Bosom cancer is disease kills runner up after neck cancer rahimBerbagai effort done to fight against the disease. Now radiation therapy and sitostatika has possibility that pursuing cancer spreading.
Bosom cancer and cervix uteri cancer is cancer type which its(the case frequency is highest among other type cancers groaning woman. In Indonesia number of bosom cancer patients occupies second rank after womb canker.
Bosom cancer becomes the root cause death at woman in various world clefts. In consequence need to strive firm to fight against cancer by the way of pursuing draught to kill growth of its(the cell is selectively, accompanied minimization business of side effects.
Forming of the cancer through four phases. At initiation step, happened mutilation of DNA or mutation, what arranges duplication of cell by compound cause of cancer ( carcinogen). Hereinafter, happened improvement of duplication of abnormal cell as result of initiation process. This phase named promotion phase.
Malignant cancer cells appearance followed with real genetic change marks development of phase progresi. At phase metatasis ( stadium four), cancer cell does expansion to other network passed vein or small channel limfe. ekspansif cell will form secondary tumor in jaringn infected.
Groaning normal cells is around [by] it, cancer also produces draught poison nelepas cancer cells from its(the mains breaking. this Poison and cancer cells will disseminate with blood stream. In consequence, frequently is found also cancer growing in other place as result of its(the metastasis. At hard cancer, often happened haemorrahage.
Specific drug to stop development of cancer cell has not also is found. Now preventive effort always is laboured with radiation therapy and sitostatika.
Bolts from the idea, Dr Edy Meiyanto Msi Apt, researcher from CCRC ( Cancer Chemoprevention Research Centre), does research to get structure which more stable with better activity from curcumin in pursuing growth of bosom cancer cell ( cell T47D).
“ Research expansion done by CCRC focused to modify curcumin molecule structure to get pharmacology activity which more baik,”jelas Edy, now takes hold of dean proxy 1 Faculty Of Pharmacy UGM.
To setle research result done by medio 2006 was, September 2006 then is done also international symposium studying about modification influence of curcumin, one of its(the analogue is result of this elite, that is Pentagamavunon-0 or 2,5-bis ( 4'-hydroxy-3’-methoxy-benzylidene)-cyclopentanon ( PGV-0).
In doing this research, Edy is not alone. Supardjan AM MS Apt, researcher that is also pharmacy lecturer UGM, stands in menyitesis and eludasi curcumin structure causing is got new analogue having structure is more stable, that is PGV-0.
Races Apoptosis Cancer Cell
Beginning of this research applies cytotoxicity test with method MTT. Namely, cell suspension in medium packed into plate 96 and incubation [by] during 24 hours at carbon dioxide incubator ( CO2). In incubation end, medium at each sumuran thrown and cleaned conspecifically certain condensation. Then, plate incubation at temperature 37 degree of celcius. Life cell will react with MTT to form purple formazan.
Process hereinafter, done observation test of proliferation kinetics of cell. proliferation of Cell is function of from cell recycle program. The method is done in the same way at cytotoxicity test with concentration of treatment differs in at to 6, 12, 24, 48, and 72.
Both tests in researching into this applies method to know potency PGV-0 as anti proliferation compound to bosom cancer cell. MTT is diabsorsi into life cell and broken [by] through reaction of reduction by reductase enzyme.
Besides, in this research got data about proliferation of cell indicating that PGV-0 and also curcumin can pursue or reduces character proliferatif bosom cancer cell. But, at certain concentration, induction of curcumin simply doesn't generate influence at life cell rate of change.
That also indicates that PGV-0 to have stronger effect to pursue proliferation of bosom cancer cell compared to krkumin.
Other excess of PGV-0 be the structure. With structure which more flat from at curcumin, enables PGV-0 to have better activity. PGV-0 also can pursue causing cell cycle also at reference apoptosis ( suicide program) bosom cancer cells.
PGV-0 as well as kukumin has the same function, that is having lever hinders growth of new vein. The matter can act as immunomodulator or imunostimulator, or can increase number of lymphocytes, increases cancer murderer, and increases specific antibody.
Stop At Certain Phase
Based on cytotoxicity test and growth profile observation of cell proves that cytotoxic potency and resistance ploliferasi to bosom cancer cell, compound PGV-0, better compared to curcumin.
The growth resistivity happened because the compound causes death of cell or pursues program cell cycleprogresion ( development of cell) becomes cell cycle arrestPGV-0 can race death of cell through apoptosis or makes cell cycle arrest as curcumin which has been tested to some cancer cells.
Incorporation analysis BrdU proves PGV-0 can pursue cell to enter stronger S phase compared to curcumin. The resistance can happened at phase G1 ( Gap1) and or S phase ( synthesis phase and replication of DNA)
Bosom Cancer Begins From Abnormal Cell
When bosom cancer starts plants? When there are growth that is below par at cells in bosom gland or gland channel. Also, can come from bosom mechanical tissue.
Cancer will emerge if(when normal cell DNA experiences damage causing causes genetic mutation. If not soon is corrected, propagation of cell which its(the DNA the breakdown is potency yields cancer cell. Though propagation of cell meant to cure timeworn cells or breakdown.
If damage of normal cell DNA not even be prevented by anti having the character of compound or vitamin and mineral oxidant or after having have come too far unintentionally formed [by] cancer cells, must soon is done emphasis to growth of the cancer cell.
To pursue metastasis ( spreading) cancer cell, must be known way of the cell disseminates. There is two way of cancer cell is having metastasis, that is through angiogenesis ( forming of new vein) and crushing of collagen which is normal cell framework.
Thereby, metastasis will be able to be pursued if(when preventable angiogenesis, whereas damage collagen can be improve;repaired by body by exploiting certain food.
For angiogenesis, cancer cell discharges growth factors. Produce of growth factors simply can be pursued by curcumin contained in turmeric, temulawak, white kunir, and PGV-0 as analogue.
Symptom which Must Be Taken heed
But, that need to be paid attention is growth of the type cancer often do not be realized. The happening of gene mutation as result of the abnormal cells triggered by an impurities entering kedalam body, like food preserver, vetsin, radioactivity, oxidant, and or matter korsinogenetik yielded by body naturally.
With blood stream and lymph stream, cancer cells and poisons yielded by it can disseminate to all our body like bone, lung and lever.
In consequence, initially at bosom cancer patient is finding bump armpit or other lymph gland bump. Even, emerges also cancer at lever and lung as its(the metastasi.
Hardly is suggested detects by the way of sarari or inspection of bosom x'self to anticipate the bosom cancer. Particularly, the cancer often found at continuation stadium. Sasari is simplest way and easy to be done, but having important meaning to detect early bosom cancer.
Sasari to Detect Early
What preventing bosom cancer? Cancer researcher at University Faculty Of Mediciness Yarsi jakarta Dr Susi Endrini MSc tells, investigates bosom, avoids fatty food, and consumption fruit and rich vegetable of antioxidant. What process and causative growing of bosom cancer cell?
Medically, bosom cancer cell grows passing three phases. Firstly, initiation or blaze outburst explosion of feeling. Second, promotion. Cancer cell does duplication to disseminate. Third phase, what endangers, be progressive phase. At the time, cell has groaned organ laimelalui vein. Originator factors growing of cancer cell, inter alia, chemicals, food, and virus. Can also genetic factor and radiation.
What its(the therapy?
There is beberap choice. Can with irradiating. If(when cancer cell has entered stadium 3 or 4, tumor is lifted [by] through surgery. Other choice of its(the therapy is chemotherapy, enters drugs. Can also is done combination of the choice.
Is your opinion about usage of PGV-0 which is curcumin analogue as bosom cancer drug?
Research about cancer cell resistance through Pentagamavunon ( PGV-0) as active kurkumin(bahan analogue encountered comedy) very potential to be more is developed again. Proven in the research, PGV-0 can pursue cell T47D which is bosom cancer cell.
Does PGV-0 can heal and minimization of side effects?
minimization of Side effects depend on reaction of to normal cell of patient body. Definitive, usually, patient kenker will experience its(the fall is hair shaped like in chemotherapy therapy.
What prevention to the disease? For prevention, earlyly can be done “ realizes” ( investigates ownself) or “ sarari” ( investigates bosom x'self). This thing can be done every bath pot is clean. Then, avoids consumes fatty food. Suggested eats fruit and vegetable containing antioxidant.
Bosom cancer is disease kills runner up after neck cancer rahimBerbagai effort done to fight against the disease. Now radiation therapy and sitostatika has possibility that pursuing cancer spreading.
Bosom cancer and cervix uteri cancer is cancer type which its(the case frequency is highest among other type cancers groaning woman. In Indonesia number of bosom cancer patients occupies second rank after womb canker.
Bosom cancer becomes the root cause death at woman in various world clefts. In consequence need to strive firm to fight against cancer by the way of pursuing draught to kill growth of its(the cell is selectively, accompanied minimization business of side effects.
Forming of the cancer through four phases. At initiation step, happened mutilation of DNA or mutation, what arranges duplication of cell by compound cause of cancer ( carcinogen). Hereinafter, happened improvement of duplication of abnormal cell as result of initiation process. This phase named promotion phase.
Malignant cancer cells appearance followed with real genetic change marks development of phase progresi. At phase metatasis ( stadium four), cancer cell does expansion to other network passed vein or small channel limfe. ekspansif cell will form secondary tumor in jaringn infected.
Groaning normal cells is around [by] it, cancer also produces draught poison nelepas cancer cells from its(the mains breaking. this Poison and cancer cells will disseminate with blood stream. In consequence, frequently is found also cancer growing in other place as result of its(the metastasis. At hard cancer, often happened haemorrahage.
Specific drug to stop development of cancer cell has not also is found. Now preventive effort always is laboured with radiation therapy and sitostatika.
Bolts from the idea, Dr Edy Meiyanto Msi Apt, researcher from CCRC ( Cancer Chemoprevention Research Centre), does research to get structure which more stable with better activity from curcumin in pursuing growth of bosom cancer cell ( cell T47D).
“ Research expansion done by CCRC focused to modify curcumin molecule structure to get pharmacology activity which more baik,”jelas Edy, now takes hold of dean proxy 1 Faculty Of Pharmacy UGM.
To setle research result done by medio 2006 was, September 2006 then is done also international symposium studying about modification influence of curcumin, one of its(the analogue is result of this elite, that is Pentagamavunon-0 or 2,5-bis ( 4'-hydroxy-3’-methoxy-benzylidene)-cyclopentanon ( PGV-0).
In doing this research, Edy is not alone. Supardjan AM MS Apt, researcher that is also pharmacy lecturer UGM, stands in menyitesis and eludasi curcumin structure causing is got new analogue having structure is more stable, that is PGV-0.
Races Apoptosis Cancer Cell
Beginning of this research applies cytotoxicity test with method MTT. Namely, cell suspension in medium packed into plate 96 and incubation [by] during 24 hours at carbon dioxide incubator ( CO2). In incubation end, medium at each sumuran thrown and cleaned conspecifically certain condensation. Then, plate incubation at temperature 37 degree of celcius. Life cell will react with MTT to form purple formazan.
Process hereinafter, done observation test of proliferation kinetics of cell. proliferation of Cell is function of from cell recycle program. The method is done in the same way at cytotoxicity test with concentration of treatment differs in at to 6, 12, 24, 48, and 72.
Both tests in researching into this applies method to know potency PGV-0 as anti proliferation compound to bosom cancer cell. MTT is diabsorsi into life cell and broken [by] through reaction of reduction by reductase enzyme.
Besides, in this research got data about proliferation of cell indicating that PGV-0 and also curcumin can pursue or reduces character proliferatif bosom cancer cell. But, at certain concentration, induction of curcumin simply doesn't generate influence at life cell rate of change.
That also indicates that PGV-0 to have stronger effect to pursue proliferation of bosom cancer cell compared to krkumin.
Other excess of PGV-0 be the structure. With structure which more flat from at curcumin, enables PGV-0 to have better activity. PGV-0 also can pursue causing cell cycle also at reference apoptosis ( suicide program) bosom cancer cells.
PGV-0 as well as kukumin has the same function, that is having lever hinders growth of new vein. The matter can act as immunomodulator or imunostimulator, or can increase number of lymphocytes, increases cancer murderer, and increases specific antibody.
Stop At Certain Phase
Based on cytotoxicity test and growth profile observation of cell proves that cytotoxic potency and resistance ploliferasi to bosom cancer cell, compound PGV-0, better compared to curcumin.
The growth resistivity happened because the compound causes death of cell or pursues program cell cycleprogresion ( development of cell) becomes cell cycle arrestPGV-0 can race death of cell through apoptosis or makes cell cycle arrest as curcumin which has been tested to some cancer cells.
Incorporation analysis BrdU proves PGV-0 can pursue cell to enter stronger S phase compared to curcumin. The resistance can happened at phase G1 ( Gap1) and or S phase ( synthesis phase and replication of DNA)
Bosom Cancer Begins From Abnormal Cell
When bosom cancer starts plants? When there are growth that is below par at cells in bosom gland or gland channel. Also, can come from bosom mechanical tissue.
Cancer will emerge if(when normal cell DNA experiences damage causing causes genetic mutation. If not soon is corrected, propagation of cell which its(the DNA the breakdown is potency yields cancer cell. Though propagation of cell meant to cure timeworn cells or breakdown.
If damage of normal cell DNA not even be prevented by anti having the character of compound or vitamin and mineral oxidant or after having have come too far unintentionally formed [by] cancer cells, must soon is done emphasis to growth of the cancer cell.
To pursue metastasis ( spreading) cancer cell, must be known way of the cell disseminates. There is two way of cancer cell is having metastasis, that is through angiogenesis ( forming of new vein) and crushing of collagen which is normal cell framework.
Thereby, metastasis will be able to be pursued if(when preventable angiogenesis, whereas damage collagen can be improve;repaired by body by exploiting certain food.
For angiogenesis, cancer cell discharges growth factors. Produce of growth factors simply can be pursued by curcumin contained in turmeric, temulawak, white kunir, and PGV-0 as analogue.
Symptom which Must Be Taken heed
But, that need to be paid attention is growth of the type cancer often do not be realized. The happening of gene mutation as result of the abnormal cells triggered by an impurities entering kedalam body, like food preserver, vetsin, radioactivity, oxidant, and or matter korsinogenetik yielded by body naturally.
With blood stream and lymph stream, cancer cells and poisons yielded by it can disseminate to all our body like bone, lung and lever.
In consequence, initially at bosom cancer patient is finding bump armpit or other lymph gland bump. Even, emerges also cancer at lever and lung as its(the metastasi.
Hardly is suggested detects by the way of sarari or inspection of bosom x'self to anticipate the bosom cancer. Particularly, the cancer often found at continuation stadium. Sasari is simplest way and easy to be done, but having important meaning to detect early bosom cancer.
Sasari to Detect Early
What preventing bosom cancer? Cancer researcher at University Faculty Of Mediciness Yarsi jakarta Dr Susi Endrini MSc tells, investigates bosom, avoids fatty food, and consumption fruit and rich vegetable of antioxidant. What process and causative growing of bosom cancer cell?
Medically, bosom cancer cell grows passing three phases. Firstly, initiation or blaze outburst explosion of feeling. Second, promotion. Cancer cell does duplication to disseminate. Third phase, what endangers, be progressive phase. At the time, cell has groaned organ laimelalui vein. Originator factors growing of cancer cell, inter alia, chemicals, food, and virus. Can also genetic factor and radiation.
What its(the therapy?
There is beberap choice. Can with irradiating. If(when cancer cell has entered stadium 3 or 4, tumor is lifted [by] through surgery. Other choice of its(the therapy is chemotherapy, enters drugs. Can also is done combination of the choice.
Is your opinion about usage of PGV-0 which is curcumin analogue as bosom cancer drug?
Research about cancer cell resistance through Pentagamavunon ( PGV-0) as active kurkumin(bahan analogue encountered comedy) very potential to be more is developed again. Proven in the research, PGV-0 can pursue cell T47D which is bosom cancer cell.
Does PGV-0 can heal and minimization of side effects?
minimization of Side effects depend on reaction of to normal cell of patient body. Definitive, usually, patient kenker will experience its(the fall is hair shaped like in chemotherapy therapy.
What prevention to the disease? For prevention, earlyly can be done “ realizes” ( investigates ownself) or “ sarari” ( investigates bosom x'self). This thing can be done every bath pot is clean. Then, avoids consumes fatty food. Suggested eats fruit and vegetable containing antioxidant.
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