PGV-o Stop breast cancer

PGV-o Stop breast cancer

Bosom cancer is disease kills runner up after neck cancer rahimBerbagai effort done to fight against the disease. Now radiation therapy and sitostatika has possibility that pursuing cancer spreading.

Bosom cancer and cervix uteri cancer is cancer type which its(the case frequency is highest among other type cancers groaning woman. In Indonesia number of bosom cancer patients occupies second rank after womb canker.

Bosom cancer becomes the root cause death at woman in various world clefts. In consequence need to strive firm to fight against cancer by the way of pursuing draught to kill growth of its(the cell is selectively, accompanied minimization business of side effects.

Forming of the cancer through four phases. At initiation step, happened mutilation of DNA or mutation, what arranges duplication of cell by compound cause of cancer ( carcinogen). Hereinafter, happened improvement of duplication of abnormal cell as result of initiation process. This phase named promotion phase.

Malignant cancer cells appearance followed with real genetic change marks development of phase progresi. At phase metatasis ( stadium four), cancer cell does expansion to other network passed vein or small channel limfe. ekspansif cell will form secondary tumor in jaringn infected.

Groaning normal cells is around [by] it, cancer also produces draught poison nelepas cancer cells from its(the mains breaking. this Poison and cancer cells will disseminate with blood stream. In consequence, frequently is found also cancer growing in other place as result of its(the metastasis. At hard cancer, often happened haemorrahage.

Specific drug to stop development of cancer cell has not also is found. Now preventive effort always is laboured with radiation therapy and sitostatika.

Bolts from the idea, Dr Edy Meiyanto Msi Apt, researcher from CCRC ( Cancer Chemoprevention Research Centre), does research to get structure which more stable with better activity from curcumin in pursuing growth of bosom cancer cell ( cell T47D).

“ Research expansion done by CCRC focused to modify curcumin molecule structure to get pharmacology activity which more baik,”jelas Edy, now takes hold of dean proxy 1 Faculty Of Pharmacy UGM.

To setle research result done by medio 2006 was, September 2006 then is done also international symposium studying about modification influence of curcumin, one of its(the analogue is result of this elite, that is Pentagamavunon-0 or 2,5-bis ( 4'-hydroxy-3’-methoxy-benzylidene)-cyclopentanon ( PGV-0).

In doing this research, Edy is not alone. Supardjan AM MS Apt, researcher that is also pharmacy lecturer UGM, stands in menyitesis and eludasi curcumin structure causing is got new analogue having structure is more stable, that is PGV-0.

Races Apoptosis Cancer Cell

Beginning of this research applies cytotoxicity test with method MTT. Namely, cell suspension in medium packed into plate 96 and incubation [by] during 24 hours at carbon dioxide incubator ( CO2). In incubation end, medium at each sumuran thrown and cleaned conspecifically certain condensation. Then, plate incubation at temperature 37 degree of celcius. Life cell will react with MTT to form purple formazan.

Process hereinafter, done observation test of proliferation kinetics of cell. proliferation of Cell is function of from cell recycle program. The method is done in the same way at cytotoxicity test with concentration of treatment differs in at to 6, 12, 24, 48, and 72.

Both tests in researching into this applies method to know potency PGV-0 as anti proliferation compound to bosom cancer cell. MTT is diabsorsi into life cell and broken [by] through reaction of reduction by reductase enzyme.

Besides, in this research got data about proliferation of cell indicating that PGV-0 and also curcumin can pursue or reduces character proliferatif bosom cancer cell. But, at certain concentration, induction of curcumin simply doesn't generate influence at life cell rate of change.

That also indicates that PGV-0 to have stronger effect to pursue proliferation of bosom cancer cell compared to krkumin.

Other excess of PGV-0 be the structure. With structure which more flat from at curcumin, enables PGV-0 to have better activity. PGV-0 also can pursue causing cell cycle also at reference apoptosis ( suicide program) bosom cancer cells.

PGV-0 as well as kukumin has the same function, that is having lever hinders growth of new vein. The matter can act as immunomodulator or imunostimulator, or can increase number of lymphocytes, increases cancer murderer, and increases specific antibody.

Stop At Certain Phase

Based on cytotoxicity test and growth profile observation of cell proves that cytotoxic potency and resistance ploliferasi to bosom cancer cell, compound PGV-0, better compared to curcumin.

The growth resistivity happened because the compound causes death of cell or pursues program cell cycleprogresion ( development of cell) becomes cell cycle arrestPGV-0 can race death of cell through apoptosis or makes cell cycle arrest as curcumin which has been tested to some cancer cells.

Incorporation analysis BrdU proves PGV-0 can pursue cell to enter stronger S phase compared to curcumin. The resistance can happened at phase G1 ( Gap1) and or S phase ( synthesis phase and replication of DNA)

Bosom Cancer Begins From Abnormal Cell

When bosom cancer starts plants? When there are growth that is below par at cells in bosom gland or gland channel. Also, can come from bosom mechanical tissue.

Cancer will emerge if(when normal cell DNA experiences damage causing causes genetic mutation. If not soon is corrected, propagation of cell which its(the DNA the breakdown is potency yields cancer cell. Though propagation of cell meant to cure timeworn cells or breakdown.

If damage of normal cell DNA not even be prevented by anti having the character of compound or vitamin and mineral oxidant or after having have come too far unintentionally formed [by] cancer cells, must soon is done emphasis to growth of the cancer cell.

To pursue metastasis ( spreading) cancer cell, must be known way of the cell disseminates. There is two way of cancer cell is having metastasis, that is through angiogenesis ( forming of new vein) and crushing of collagen which is normal cell framework.

Thereby, metastasis will be able to be pursued if(when preventable angiogenesis, whereas damage collagen can be improve;repaired by body by exploiting certain food.

For angiogenesis, cancer cell discharges growth factors. Produce of growth factors simply can be pursued by curcumin contained in turmeric, temulawak, white kunir, and PGV-0 as analogue.

Symptom which Must Be Taken heed

But, that need to be paid attention is growth of the type cancer often do not be realized. The happening of gene mutation as result of the abnormal cells triggered by an impurities entering kedalam body, like food preserver, vetsin, radioactivity, oxidant, and or matter korsinogenetik yielded by body naturally.

With blood stream and lymph stream, cancer cells and poisons yielded by it can disseminate to all our body like bone, lung and lever.

In consequence, initially at bosom cancer patient is finding bump armpit or other lymph gland bump. Even, emerges also cancer at lever and lung as its(the metastasi.

Hardly is suggested detects by the way of sarari or inspection of bosom x'self to anticipate the bosom cancer. Particularly, the cancer often found at continuation stadium. Sasari is simplest way and easy to be done, but having important meaning to detect early bosom cancer.

Sasari to Detect Early

What preventing bosom cancer? Cancer researcher at University Faculty Of Mediciness Yarsi jakarta Dr Susi Endrini MSc tells, investigates bosom, avoids fatty food, and consumption fruit and rich vegetable of antioxidant. What process and causative growing of bosom cancer cell?

Medically, bosom cancer cell grows passing three phases. Firstly, initiation or blaze outburst explosion of feeling. Second, promotion. Cancer cell does duplication to disseminate. Third phase, what endangers, be progressive phase. At the time, cell has groaned organ laimelalui vein. Originator factors growing of cancer cell, inter alia, chemicals, food, and virus. Can also genetic factor and radiation.

What its(the therapy?

There is beberap choice. Can with irradiating. If(when cancer cell has entered stadium 3 or 4, tumor is lifted [by] through surgery. Other choice of its(the therapy is chemotherapy, enters drugs. Can also is done combination of the choice.

Is your opinion about usage of PGV-0 which is curcumin analogue as bosom cancer drug?

Research about cancer cell resistance through Pentagamavunon ( PGV-0) as active kurkumin(bahan analogue encountered comedy) very potential to be more is developed again. Proven in the research, PGV-0 can pursue cell T47D which is bosom cancer cell.

Does PGV-0 can heal and minimization of side effects?

minimization of Side effects depend on reaction of to normal cell of patient body. Definitive, usually, patient kenker will experience its(the fall is hair shaped like in chemotherapy therapy.

What prevention to the disease? For prevention, earlyly can be done “ realizes” ( investigates ownself) or “ sarari” ( investigates bosom x'self). This thing can be done every bath pot is clean. Then, avoids consumes fatty food. Suggested eats fruit and vegetable containing antioxidant.

ASI Can Give Protection To Overcome Bosom Cancer

ASI Can Give Protection To Overcome Bosom Cancer

Kiosk Angeles ( ANTARA News) - Mother Milk Water Supply ( ASI) can give wide protection overcomes possibility that bosom cancer for above woman 25 years having chlid, said result a study broadcasted by Fakultas Medis University of Southern California.

Some former studies has showed that for woman who is delivering birth before age 25 years and has many chlids is protecting it from certain type of bosom cancer, while postponement has chlid to relate to risk larger ones to be attacked bosom cancer.

most Important finding about the new study is giving of ASI seems to reduced risk is attacked [by] bosom cancer happened if a woman had chlid at the age of further in life his(its, said Dr. Giske Ursin, lecturer assistant in preventive drug in Fakultas Medis University of Southern California and leader of researcher in the study.

Result of the study announced at annual meeting " American Association for Cancer Research" in Los Angeles, United States ( ACE).

" While more and more many womens possibly chooses to delay pregnancy until after they are having age 25 years, important of keep in mind that giving of ASI provides protection to positive tumor and estrogen receptor negativity and progesterone," said Ursin, like cited [by] Reuters.

Woman who attacked bosom cancer which is hormone receptor negativity has prognosis which far worse compared to woman with other type of bosom cancer.

The the researchers woman data analysis who is having age 55 years and older again -- including 995 bosom cancer patients invasif-dan discovers that giving of ASI seems to have nonchalant protection impact when they start bears.

That thing, according to him(her, important because having many chlids only give protection among woman is strarting has chlid at the age of more early.

" Evidence indicates that woman who is having chlid at the age of after 25 years can lessen risk they are attacked [by] cancer payudaya by choosing to give ASI," said Ursin.

According to data Sensus AS, 25 years is woman average life in AS has first chlid.

The study fund by National Institute of Child Healt and Human Development and by National Cancer Institute.

Burning Flesh Devotee Is Having to Hits Bosom Cancer

Burning Flesh Devotee Is Having to attack Hits Bosom Cancer

New York ( ANTARA News) - Woman of menopause liking burning flesh ( barbeque) and smoked meat berisiko is hit [by] bosom cancer, causing is suggested that also more eaten fruit and vegetable, suggestion a new research.

Dr Susan E Steck from University of South Carolina, Columbia, and its(the friends finding that woman of menopause which during its(the life many eating roast, smoked meat or burning flesh, has risk 47 higher % is hit [by] bosom cancer.

The research also shows the penyuka flesh which seldom eat fruit and vegetable to have risk 74 higher % is hit [by] bosom cancer.

Woman of old has not menopause become penyuka flesh is not detected has relationship with bosom cancer.

The researchers nor finds strong relationship between strippers is not his(its becomes carnivor with bosom cancer at woman who has not experienced menopause.

The finding " supports prevention guidance of cancer that is now is recommended" that is eating more result of crop and lessens eating red processing flesh or flesh, said Steck in interview with " Reuters Health".

On the other side, s(he warns, the research has found existence of tightly relationship, even not manifestly, what indicates that ripe flesh is cancer cause.

Possible other factors also becomes cause, for example high fat content at the flesh products.

Aromatic polycyclic of hydrocarbon and heterosiklik amino known as carcinogen coming from ripe flesh at high temperature, writes Steck and its(the team in their report.

Aromatic polycyclic of hydrocarbon there is in roast, burning flesh and smoked meat ( also in many other foods).

Fleshy above all fried and roast, contains heterosiklik amino is having rate height.

Drinks Milk, Degrades Bosom Cancer Risk

Drinks Milk, Degrades Bosom Cancer Risk

By: I. Albiner Siagian, MSI PENGAJAR BAGIAN GIZI FKM UNIVERSITAS SUMATERA UTARA, Field

Milk benefit had no doubt again. Most all nutrients which there is in up to standard milk. Protein and milk fat measures up to ketecernaan which high. Vitamin content and milk mineral also relative complete.

Milk can be consumed in so many form. Fresh something or something in the form of terolah, milky of powder or beloved heavy cream. Man also consumes milk from food product containing milk, like cheese, ice-cream, and yogurt.

But, there are still different idea about consumption of this milk. There is group expressing that consuming milk every day not good for health, especially vascular disease like vein stricture. Its(the argument is, milk increases blood cholesterol rate becoming heart sickness risk factor. Second, existence of positive relationship between produce of milks average of per capita with death as result of heart sickness in a number of states.

Other group supports the role of milk at degradation of risk various degenerative disease, like heart sickness, hypertension, and cancer. Newest research in Norwegian supports the matter.

Hjartäker with its(the kolega from Institute of Community Medicine, University Tromso, Norwegia, through its(the publication at International Journal of Cancer, proves that mengonsumi three glasses or more milk every day can reduce risk is hit [by] bosom cancer at woman pramenopause.

Pass research of cohort the Norwegian Women and Cancer Study, they check 48844 womens during six years two months. consumption of Milk is measured by sending consumption history form of food to responder. During the range of time, team Hjartäker finds 317 bosom cancer patient cases.

Simply consumed milk since negative interconnected childhood with case of bosom cancer at the time of they age 34-39 years ( pramenopause). Means that consumes milk since childhood can reduce risk is hit [by] bosom cancer.

consumption of Milk during adult also reduces bosom cancer risk after corrected according to factor hormonal, body mass index, physical activity, and consumption of alcohol. Woman that is is not consumes milk to face risk is hit [by] bosom cancer 2 bigger times than womens consuming milk 3 glass or more milk every day.

Other benefit

* Newest research also lays open that consuming milk regularly reduces disease risk related to disparity at vein, like stroke and heart.

Elwood from Universitas Ulster, Irlandia, with its(the kolega, in publication at Journal of Epidemiology Community Health the year 2005 proving that consuming milk can reduce risk stroke and heart sickness.

In the Caerphilly Cohort Study Elwood and kith observes 665 mans Wales age 45-49 years. The responders is asked to notes consumption of its(the food during one week. Result of his(its, average and consumption median value of responder milk is 210 cc and 195 cc per day ( more or less one glasses per day).

Elwood and its(the kolega finding that man is consuming its(the milk above median (> 1 glass per day) has risk twice the small is hit [by] stroke. The same also valids for heart sickness. Risk is hit heart attack is 100:88 between men who is consuming milk below(under one glasses per day and consuming above milk one glasses per day. This obedient fact of ground with the same researcher finding by 2403 elderly mans in Wales with consumption history method of food.

Finding Elwood and kith also strenghtened by research in Puerto Riko hooking;correlating consumption of milk with hypertension risk, one of risk factor for stroke and heart attack. At this research, Garcia and friends proves that man which is not consumes milk to have hypertension risk 2 higher times than they consuming milk.

Either Hjartäker and kith and also Elwood and its(the kolega is not able yet to ascertain how milk to have protector effect to neoplastic disease, stroke, and heart. In consequence, required further study to know component does in milk having the functional effect.

Might be, quality of gizi which is good and composition of nutrient that is snugly in milk is factor penurun the risk. Or, that because of the increasing of body endurance referring to the consuming milk.

Darling, now consumption of milk average of Indonesia public still be very low, 5,5 litres per kapita/tahun or equivalent with interest less 50 drips one day. This number a long way off below(under consumption average of at India public, Philippine, and Thailand which is each 75, 25, and 22 litres per kapita/tahun.*

Bosom cancer gene is found

Bosom cancer gene is found

The scientists has developed new technique to identify gene enlarging possibility that woman is hit [by] bosom cancer.

Scientist hopes the technique result will one blood tests which will lay open risk a woman is hit [by] the cancer.

The researchers tells, new technique of that quickens identification of gene and possibly enables all ygen related to bosom cancer.

Cancer Research UK depicts development " hardly signifikan".

New invention

The scientists finds two genes having responsibility to bosom cancer two last year.

Now, new research led by Cambridge Research Institute property of British cancer institute, Cancer Research UK, which result of his(its published in journal the Nature journal, finds five genes again.

In the past is required some a decay to trace patient DNA and finds damage gene, but new technique of this dikembangan now enables the process steps faster.

This technique compares patient DNA key parts with healthy volunteer DNA and the difference concluded as gene that is possibly causes the disease.

Process bases on this computer can be complete in a few hours and the scientists is sure that in a few month, researcher can find all genes involving in development of bosom cancer.

To find four the new genes, the scientists must filter approximant DNA 50000 womens, semi from the amounts healthy other bosom cancer patient and half.

Gene Has Strong Ties to Stomach Cancer

SUNDAY, June 3 (HealthDay News) -- Canadian researchers say they've identified genetic mutations linked to a form of stomach cancer called hereditary diffuse gastric cancer.

They did so by conducting genetic analyses of members of 38 families with the disease.

The mutations they identified in the study participants were due to both common ancestry and independent mutational events.

Hereditary diffuse gastric cancer (HDGC) is caused by mutations in the gene CDH1. Of the 38 families in the study, 26 families had at least two gastric cancer cases, with one case of HDGC in a person younger than age 50; 12 families had either a single case of HDGC in a person younger than age 35 or multiple cases of HDGC in people older than age 50.

The researchers from the BC Cancer Agency in Vancouver identified 13 mutations (six newly discovered) in 15 of the 38 families -- 40 percent.

"Our results confirm that between 30 percent and 40 percent of families with a positive family history of gastric cancer and more than 50 percent of families with 2 diffuse gastric cancer cases diagnosed prior to age 50 years will carry germline mutations in the CDH1 gene," the study authors wrote.

The study was to be presented Sunday at the annual meeting of the American Society of Clinical Oncology in Chicago, and will also appear in the June 6 issue of the Journal of the American Medical Association.

In an accompanying editorial in JAMA, Dr. Kirsten N. Kangelaris and Dr. Stephen B. Gruber of the University of Michigan wrote that this kind of study helps "clinicians understand and manage HDGC with more precision, helps families understand the risks accompanying a mutation in CDH1, and helps population geneticists better understand the distribution of recurrent mutations in CDH1."

Gene Has Strong Ties to Stomach Cancer

SUNDAY, June 3 (HealthDay News) -- Canadian researchers say they've identified genetic mutations linked to a form of stomach cancer called hereditary diffuse gastric cancer.

They did so by conducting genetic analyses of members of 38 families with the disease.

The mutations they identified in the study participants were due to both common ancestry and independent mutational events.

Hereditary diffuse gastric cancer (HDGC) is caused by mutations in the gene CDH1. Of the 38 families in the study, 26 families had at least two gastric cancer cases, with one case of HDGC in a person younger than age 50; 12 families had either a single case of HDGC in a person younger than age 35 or multiple cases of HDGC in people older than age 50.

The researchers from the BC Cancer Agency in Vancouver identified 13 mutations (six newly discovered) in 15 of the 38 families -- 40 percent.

"Our results confirm that between 30 percent and 40 percent of families with a positive family history of gastric cancer and more than 50 percent of families with 2 diffuse gastric cancer cases diagnosed prior to age 50 years will carry germline mutations in the CDH1 gene," the study authors wrote.

The study was to be presented Sunday at the annual meeting of the American Society of Clinical Oncology in Chicago, and will also appear in the June 6 issue of the Journal of the American Medical Association.

In an accompanying editorial in JAMA, Dr. Kirsten N. Kangelaris and Dr. Stephen B. Gruber of the University of Michigan wrote that this kind of study helps "clinicians understand and manage HDGC with more precision, helps families understand the risks accompanying a mutation in CDH1, and helps population geneticists better understand the distribution of recurrent mutations in CDH1."